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Name: Dr. Mariam Anees
Designation: Associate Professor
Department: Biochemistry (BMB)


Qualifications:
  • Ph.D. (Molecular Biology/Malignant Diseases), Medical University of Vienna, Vienna, Austria - 2012
  • M. Phil. (Endocrinology), Quaid-i-Azam University, Islamabad, Pakistan - 2007
  • M.Sc. (Biochemistry/Molecular Biology), Quaid-i-Azam University, Islamabad, Pakistan - 2005
  • B.Sc. (Zoology, Botany, Chemistry), University of the Punjab, Lahore, Pakistan    - 2003


Phone: +92-51 9064-3224
Email: mariam@qau.edu.pk
Status: On Job
Other Weblink: https://www.researchgate.net/profile/Mariam_Anees

View Resume

Research Interests Publications Conferences Research Projects

  • Interaction of signal transduction pathways and consequent effect on cancer pathogenesis.
  • Cancer Immune Surveillance with reference to the involvement/contribution of specific immune cells.
  • Testing of novel compounds for their anti-cancer activity in vitro and in vivo.
  • TNF-Related Apoptosis-Inducing Ligand (TRAIL) pathway.
  1. Apoptosis of Leukemia Cells by Ocimum basilicum Fractions Following TNF alpha Induced Activation of JNK and Caspase 3. Rehan T, MacEwan D, Shah N, Rehan T, Tahira R, Murad S, Anees M, Murtaza I, Farman M, Sultan A (2019) Current Pharmaceutical Design [Epub ahead of print].
  2. A Novel Homozygous Frameshift Variant in XYLT2 Causes Spondyloocular Syndrome in a Consanguineous Pakistani Family. Kausar M, Chew EGY, Ullah H, Anees M, Khor CC, Foo JN, Makitie O, Siddiqi S (2019) Frontiers in Genetics 10:144.
  3. Interplay of N acetyl cysteine and melatonin in regulating oxidative stress-induced cardiac hypertrophic factors and microRNAs. Ali T, Mushtaq I, Maryam S, Farhan A, Saba K, Jan MI, Sultan A, Anees M, Duygu B, Hamera S, Tabassum S, Javed Q, da Costa Martins PA, Murtaza I (2019) Archives of Biochemistry and Biophysics 661:56-65.
  4. Novel mutation G324C in WNT1 mapped in a large Pakistani family with severe recessively inherited Osteogenesis Imperfecta. Kausar M, Siddiqi S, Yaqoob M, Mansoor S, Makitie O, Mir A, Khor CC, Foo JN, Anees M (2018) Journal of Biomedical Science 25(1):82.
  5. Recessive multiple epiphyseal dysplasia - Clinical characteristics caused by rare compound heterozygous SLC26A2 genotypes. Kausar M, Mäkitie RE, Toiviainen-Salo S, Ignatius J, Anees M, Mäkitie O (2018) European Journal of Medical Genetics pii: S1769-7212(18)30181-2.
  6. In vitro bioactivities and subacute toxicity study of O. basilicum, T. vulgaris and R. officinalis. Rehan T, Tahira R, Ullah H, Tareen U, Rehan T, Anees M, Murtaza I, Sultan A (2018) Turkish Journal of Biochemistry 43.10.1515/tjb-2017-0267.
  7. Interplay of mitochondria apoptosis regulatory factors and microRNAs in valvular heart disease. Jan MI, Khan RA, Ali T, Bilal M, Bo L, Sajid A, Malik A, Urehman N, Waseem N, Nawab J, Ali M, Majeed A, Ahmad H, Aslam S, Hamera S, Sultan A, Anees M, Javed Q, Murtaza I (2017) Archives of Biochemistry and Biophysics 633:50-57.
  8. In-vitro antileishmanial potential of peptide drug hirudin. Khan H, Nadhman A, Azam SS, Anees M, Khan I, Ullah I, Sohail MF, Shahnaz G, Yasinzai M (2017) Chemical Biology & Drug Design 89(1):67-73.
  9. Rare β-Globin Gene Mutations in Pakistan. Hussain A, Ahmed S, Ali N, S Mailk H, Anees M, Chuahdry AH, Ahmed P (2017) Hemoglobin 41(2):100-103.
  10. A Recurrent Mutation in CTSK Gene is Responsible for Autosomal Recessive Pycnodysostosis in Consanguineous Pakistani Families. Kausar M, Ashraf N, Hayat F, Hashmi AH, Siddiqi S, Anees M (2017) Pakistan Journal of Zoology 49(5):1797-1802.
  11. Role of nutrients in bacterial biosurfactant production and effect of biosurfactant production on petroleum hydrocarbon biodegradation. Khan AHA, Tanveer S, Ali S, Anees M, Sultan A, Iqbal M, Yousaf S (2017) Ecological Engineering 104(A):158-164.
  12. Data of expression status of miR- 29a and its putative target mitochondrial apoptosis regulatory gene DRP1 upon miR-15a and miR-214 inhibition. Jan MI, Khan RA, Malik A, Ali T, Bilal M, Bo L, Sajid A, Urehman N, Waseem N, Nawab J, Ali M, Majeed A, Ahmad H, Aslam S, Hamera S, Sultan A, Anees M, Javed Q, Murtaza I (2017) Data in Brief 16:1000-1004.
  13. The reduction of chromium (VI) phytotoxicity and phytoavailability to wheat (Triticum aestivum L.) using biochar and bacteria. Khan AHA, Hussain I, Zaman B, Anees M, Iqbal M, Soja G, Linde C, Yousaf S (2017) Applied Soil Ecology 114:90-98.
  14. Clinical Role of HER2 gene Amplification and chromosome 17: A cohort Study on 154 Immunohistochemically-Equivocal Cases of Pakistani Invasive Breast Carcinoma Patients. Murtaza I, Anees M, Sultan A (2016) Tumor Biology 37(7):8665-72.
  15. Extracellular vesicles in ovarian cancer: applications to tumor biology, immunotherapy and biomarker discovery. Nawaz M, Fatima F, Nazarenko I, Ekström K, Murtaza I, Anees M, Sultan A, Neder L, Camussi G, Valadi H, Squire JA, Kislinger T (2016) Expert Review of Proteomics 13(4):395-409.
  16. Role of nutrients and illuminance in predicting the fate of fungal mediated petroleum hydrocarbon degradation and biomass production. Ali Khan AH, Tanveer S, Anees M, Muhammad YS, Iqbal M, Yousaf S.  (2016) Journal of Environmental Management 176:54-60.
  17. Effects of illuminance and nutrients on bacterial photo-physiology of hydrocarbon degradation. Khan AH, Anees M, Arshad M, Muhammad YS, Iqbal M, Yousaf S (2016) Science of the Total Environment 557-558:705-11.
  18. The erratic antibiotic susceptibility patterns of Escherichia coli and Klebsiella pneumoniae isolates causing urinary tract infections. Ahmed I, Sajed M, Sultan A, Murtaza I, Yousaf S, Maqsood B, Vanhara P, Anees M (2015) EXCLI Journal 14:916-25.
  19. Tumor suppressor candidate 3 (TUSC3) prevents the epithelial-to mesenchymal transition and inhibits tumor growth by modulating the endoplasmic reticulum stress response in ovarian cancer cells. Kratochvílová K, Horak P, Ešner M, Souček K, Pils D, Anees M, Tomasich E, Dráfi F, Jurtíková V, Hampl A, Krainer M, and Vaňhara P (2015) International Journal of Cancer 137(6):1330–40.
  20. Effect of Maternal Iodine Supplementation on Thyroid Function and Birth Outcome in Goiter Endemic Areas. Anees M, Anis RA, Yousaf S, Murtaza I, Sultan A, Arslan M, Shahab M (2015) Current Medical Research and Opinion 31(4):667-74.
  21. The potential evasion of immune surveillance in MALT lymphoma by DcR2-mediated upregulation of NF-ĸB. Anees M, Horak P, Schiefer AI, Perco P, Vanhara P, El-Gazzar A, Müllauer L, Streubel B, Raderer M, Krainer M (2015) Leukemia & Lymphoma 56(5):1440-9.
  22. TUSC3 Loss Alters the ER Stress Response and Accelerates Prostate Cancer Growth in vivo.
    Horak P, Tomasich E, Vanhara P, Kratochvilova K, Anees M, Marhold M, Lemberger C, Gerschpacher M, Horvat R, Sibilia M, Pils D, Krainer M (2014) Scientific Reports 4:3739.
  23. Loss of the oligosaccharyl transferase subunit TUSC3 promotes proliferation and migration of ovarian cancer cells. Vaňhara P, Horak P, Pils D, Anees M, Petz M, Gregor W, Zeillinger R, Krainer M (2013) International Journal of Oncology 42(4):1383-9.
  24. Methylation status of TUSC3 is a prognostic factor in ovarian cancer. Pils D, Horak P, Vanhara P, Anees M, Petz M, Alfanz A, Gugerell A, Wittinger M, Gleiss A, Auner V, Cacsire-castillo D, Zeillinger R, Ioana Braicu E,  Sehouli J, Krainer M (2013) Cancer 119(5):946-54.
  25. Study of the effect of 26RF- and 43RF-amides on Testosterone and Prolactin secretion in the adult male rhesus monkey (Macaca mulatta). Wahab F, Salahuddin H, Anees M, Leprince J, Vaudry H, Tena-Sempere M, Shahab M (2012) Peptides 36(1):23-8.
  26. hVp37A status determines prognosis and cetuximab sensitivity in ovarian cancer. Wittinger M, Vanhara P, El-Gazzar A, Brenner B, Pils D, Anees M, Grunt TW, Sibilia M, Holcmann M, Horvat R, Schemper M, Zeillinger R, Schoefer C, Dolznig H, Horak P, Krainer M (2011) Clinical Cancer Research 17(24):7816-27.
  27. Recurrence free survival in prostate cancer is related to increased stromal TRAIL expression. Anees M, Horak P, El-Gazzar A, Susani M, Heinze G, Perco P, Pangerl T, Loda M, Lis R, Krainer M, Oh WK (2011) Cancer 117(6):1172-82.
  28. Natural Immunity Enhances the Activity of a DR5 Agonistic Antibody and Carboplatin in the Treatment of Ovarian Cancer. El-Gazzar A, Perco P, Eckelhart E, Anees M, Sexl V, Mayer B, Liu Y, Mikulits W, Horvat R, Pangerl T, Zheng D, Krainer M (2010) Molecular Cancer Therapeutics 9(4):1007-18.
  29. The role of c-FLIPL in ovarian cancer: Chaperoning tumor cells from immunosurveillance and increasing their invasive potential. El-Gazzar A, Wittinger M, Perco P, Anees M, Horvat R, Mikulits W, Grunt TW, Mayer B, Krainer M (2010) Gynecologic Oncology 117(3):451-9.
  1. Exploring the efficacy of conjugated nanoparticles with chemotherapy against benzene induced leukemia. Siddique MH, Bukhari S, Sabir U, Khan IU, Anees M. 3rd National Conference on Emerging Trends in Bioinformatics and Biosciences, Department of Bioinformatics, Hazara University, Mansehra, KPK, Pakistan. October 3-5, 2019.
  2. Potential of cell free mitochidrial DNA as a marker of disease severity in viral infections. Ali Z, Masood MF, Bukhari S, Shahzadi I, Muzaffar M, Waseem S, Ahmed I, Anis RA, Akhtar N, Sultan A, Anees M. 3rd National Conference on Emerging Trends in Bioinformatics and Biosciences, Department of Bioinformatics, Hazara University, Mansehra, KPK, Pakistan. October 3-5, 2019.
  3. Effects of cerium oxide nanoparticles on molecular machinery in benzene induced leukemia. Essa A, Bukhari S, Siddique MH, Khan IU, Anees M. 3rd National Conference on Emerging Trends in Bioinformatics and Biosciences, Department of Bioinformatics, Hazara University, Mansehra, KPK, Pakistan. October 3-5, 2019.
  4. Anti-leukemic and immunomodulatory effects of combined therapy of cinnamon and doxorubicin in benzene induced leukemia. Bukhari S, Khan IU, Siddique MH, Sabir U, Anees M. 3rd National Conference on Emerging Trends in Bioinformatics and Biosciences, Department of Bioinformatics, Hazara University, Mansehra, KPK, Pakistan. October 3-5, 2019.
  5. Efficacy of Artemesinin as silica based nanomedicine against benzene induced leukemia. Siddique MH, Ziad R, Gull S, Anees M. 6th International Conference on Biological and Computational Sciences, CUST, Islamabad, Pakistan. December 13, 2018.
  6. KAP study of community residents regarding Maternal, Newborn and Child Health in Islamabad. Anees M, Anis RA, Mahmood MA. 9th Annual Public Health Conference, Health Services Academy,             Islamabad, Pakistan. December 4-5, 2018.
  7. Exploration of combined efficacy of chemotherapy and naturopathy against leukemia. Naeem A, Bukhari S, Anees M. 1st International Conference on Medicinal Chemistry and Drug Discovery by Royal Society of Chemistry, COMSTECH, Islamabad, Pakistan. October 18-19, 2018.
  8. Evaluation of Pharmacological properties of purified Artemisinin coated mesoporous silica nanoparticles. Ziad R, Gull S, Anees M. 1st International Conference on Medicinal Chemistry and Drug Discovery by Royal Society of Chemistry, COMSTECH, Islamabad, Pakistan. October 18-19, 2018.
  9. Exploration of combined effect of naturopathy and chemotherapy against benzene-induced leukmia. Naeem A, Bukhari S, Anees M. 2nd National Conference on Emerging Trends in Bioinformatics and Bioscience, Mansehra, KPK, Pakistan. August 9-11, 2018.
  10. Correlation of death receptors and NF-kappaB in prostate cancer. Anees M. 1st International Conference on Advances in Drug Discovery and Development, NARC, Islamabad, Pakistan, January 3-5, 2018. 
  11. Role of metallothionein in the pathogenesis of prostate cancer. Hamid S, Anees M. AACR Conference: Prostate Cancer: Advances in Basic, Translational and Clinical Research, Orlando, Florida, USA. December 02-05, 2017.
  12. δ16HER2 positive breast tumors show invasive phenotype and over expression of growth receptors. Shahzad K, Sultan A, Anees M. 2nd International Symposium on advances in Molecular Biology in plants and health sciences, CEMB, University of Punjab, Lahore, Pakistan. 21-23 November 2017.
  13. HER2 splice variant δ16HER2 governs oncogenic and metastatic transformation in higher grade breast tumors. Shahzad K, Sultan A, Anees M. International conference on prospects and trends in molecular Biosciences, Institute of Biochemistry and Biotechnology, University of Punjab, Lahore, Pakistan. October 23-24, 2017.
  14. Molecular Interaction of Apoptotic and Survival Machineries in Transformed Cells of the Cervix. Zahid S, Mehreen R, Anees M. 13th Biennial Conference on Recent Advances & Challenges in Molecular Biology, Biochemistry and Biotechnology, Abbottabad, Pakistan. August 25-28, 2016.
  15. Characterization of the Role of TRAIL Receptor 4 in Tumor Escape and Cellular Survival.  Mehreen R, Zahid S, Anees M. 13th Biennial Conference on Recent Advances & Challenges in Molecular Biology, Biochemistry and Biotechnology, Abbottabad, Pakistan. August 25-28, 2016.
  16. Impact of Infant and Young Child Feeding (IYCF) Practices on Nutritional Status of Children. Anees M, Anis RA, Malik RA. 4th International Conference and Exhibition on Nutrition, Chicago, Illinois, USA. October 26-28, 2015.
  17. Regulation of TRAIL and NF-kappaB Pathways in Ovarian Cancer. Anees M, Batool U, Bukhari S. Advances in Ovarian Cancer Research: Exploiting Vulnerabilities, Orlando, Florida, USA.  October 17-20, 2015.
  18. Estimation of Anti-Leishmanial Properties of Anti-coagulant Drug Hirudin. Khan H, Anees M.  4th International Molecular Biology and Biotechnology Congress & Conference on Life Sciences Research, Islamabad, Pakistan. September 04-06, 2015.
  19. Synthesis and Characterization of Gold Nanoparticles with self-assembled Ferrocene thiophenol as Biological Probe. Hussain MS, Anees M.  4th International Molecular Biology and Biotechnology Congress & Conference on Life Sciences Research, Islamabad, Pakistan. September 04-06, 2015.
  20. The antibiotic susceptibility patterns of bacterial isolates causing urinary tract infections. Ahmed I, Anees M.  4th International Molecular Biology and Biotechnology Congress & Conference on Life Sciences Research, Islamabad, Pakistan. September 04-06, 2015.
  21. Exploration of FLICE Inhibitory Protein in the pathogenesis of MALT lymphoma. Butt SK, Nisar L, Anees M.  Combio2015 Conference, Melbourne, Australia. September 27-October 1, 2015.
  22. Syphilis and HIV/AIDS among High Risk Groups: A Cross-Sectional Study from Rawalpindi, Pakistan. Raza H, Waheed U, Anees M. 5th Annual Public Health Conference, Health Services Academy, Islamabad, Pakistan. December 11-12, 2014.
  23. National Food Safety Scenario and Strategies for Improvement. Anis RA, Aurangzeb, Anjum F, Anees M.  International Congress, University of Agriculture Faisalabad, Pakistan. October 14-16, 2013.
  24. Anomalies of TRAIL Pathway in MALT Lymphoma. Anees M, Horak P, Schiefer AI, Perco P, Müllauer L, Streubel B, Raderer M, Krainer M. International Conference on the Applications of Molecular Biology in Medicine and Agriculture, Islamabad, Pakistan, August 20-22, 2013, abstract # 61.
  25. Loss of death receptor 5 expression in plasmacytic MALT Lymphoma is a common event and is associated with genetic aberrations. Anees M, Horak P, Müllauer L, Streubel B, Raderer M, Krainer M. 102nd Annual meeting of the AACR, Orlando, Florida, USA, April 2–6, 2011, abstract # 4777.
  26. Genetic anomalies in MALT Lymphoma are associated with the loss of death receptor5. Anees M, Horak P, Müllauer L, Streubel B, Raderer M, Krainer M. 7th YSA PhD Symposium, Medical University of Vienna, Vienna, Austria, June 15–16, 2011, abstract # P06.
  27. The impact of tumor-infiltrating natural killer cells on ovarian cancer progression. El-gazzar A, Eckelhart E, Perco P, Anees M, Horvat R, Sexl V, Krainer M. 102nd Annual meeting of the AACR, Orlando, Florida, USA, April 2–6, 2011, abstract # 3661.
  28. ‘TRAIL’ to Tumor Immune Surveillance. Anees M. International workshop on Advances in Molecular and Cancer Biology, Brno, Czech Republic, November 11-12, 2010, abstract # 01.
  29. TRAIL in tumor microenvironment influences prostate cancer survival. Anees M, Horak P, El-GazzarA, Pangerl T, Susani M, Oh W, Krainer M. 5th PhD Symposium, Medical University of Vienna, Vienna, Austria, June 17–19, 2009, abstract # P04.
  30. Characterization of the TRAIL pathway in a syngenic mouse model of ovarian cancer. El-gazzar A, Anees M, Horvat R, Mayer B, Krainer M. 100th Annual meeting of the AACR, Denver, Colorado, USA, April 18–22, 2009, abstract # 5128.
  31. Combination of DR5 agonistic antibody and chemotherapy eliminates ovarian cancer in mice. El-Gazzar A, Perco P, Eckelhart E, Anees M, Sexl V, Mayer B, Krainer M. 5th PhD Symposium, Medical University of Vienna, Vienna, Austria, June 17–19, 2009, abstract P20.
  32. Evidence that evolutionary conserved RF amide neuropeptides stimulate prolactin secretion in the adult male rhesus monkey (Macacamulatta). Salahuddin H, Wahab F, Anees M, Leprince J, Vaudry H, Tena-Sempere M, Shahab M. 1st South Asian Conference of Physiological Societies & 11th Biennial Conference of Pakistan Physiological Society on “Physiology Updates – Trends, Opportunities & Challenges”, Islamabad, Pakistan, November 10-12, 2008.
  33. Kisspeptin does not directly stimulate testosterone secretion in the male rhesus monkey. Irfan S, Anees M, Zaman W, Shahab M. International Symposium on Endocrinology and Reproductive Sciences, Lahore University of Health Sciences, Lahore, Pakistan, February 13-14, 2007.
  • URF Grant – Elucidation of Coefficacy of Chemotherapy and Naturopathy against Leukemia [PKR 75,000] 2019-20
  • HEC, NRPU Grant – Molecular Characterization of HIV- Strain in Pakistani Population [PKR 5.01 Million] 2017- 20
  • URF Grant – Exploration of the Interplay between Death and Decoy Receptors in Human Cancers [PKR 100,000] 2017-18
  • COMSTECH TWAS Grant – To Study the Role of Decoy Receptors in NF-kappaB Induction in Human Cancers [US$ 4000] 2015-16
  • URF Grant – Characterization of the Role of DcR2 in Cellular Survival with reference to NF-kappaB Induction [PKR 70,000] 2015-16
  • URF Grant – Role of Heavy Metal induced Metallothioneine production and ubiquitous expression in the pathogenesis of Ovarian Cancer [PKR 40,000] 2014-15
  • HEC, SRGP Grant – To Elucidate the Expression of TRAIL Pathway Components in Various Cancer Types [PKR 0.5 Million] 2013-15
  • URF Grant – Current Antimicrobial Susceptibility Patterns of Escherichia coli species causing Urinary Tract Infection [PKR 75,000] 2013-14
  • URF Grant – To Study the Crosstalk of NF-κB and TRAIL Pathways in Human Cancers [PKR 48,000] 2012-13

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