Biochemical Signaling

Role of micro RNAs

In Cardiovascular, associated metabolic diseases, Apoptosis, Neuro-degeneration 

• Tetra aniline-based polymers ameliorate BPA-induced cardiotoxicity in Sprague Dawley rats, in silico and in vivo analysis. Ishtiaq A, Mushtaq I, ……. Murtaza I*. Life Sciences, Oct, 2024. 358 (123104) https://doi.org/10.1016/j.lfs.2024.123104.
• Redox Regulation in Hematology and Stem Cell Research.  Mushtaq I, Hussain K, Ishtiaq A, Murtaza I*.. May, 2024, Reference Module in Biomedical Sciences, Elsevier, ISBN 9780128012383, doi.org/10.1016/B978-0-443-15717-2.00114-1.
• Non-Coding RNAs in Hematology and Stem Cell Research,  Hussain K,    Ishtiaq A,  Mushtaq I, Murtaza I*. May, 2024, Reference Module in Biomedical Sciences, Elsevier, ISBN 9780128012383, doi.org/10.1016/B978-0-443-15717-2.00113-X.
• Stem Cells Signaling Modulators in Hematological Diseases. Ishtiaq A, Hussain K, Mushtaq I, Murtaza I*. Feb., 2024. Reference Module in Biomedical Sciences. doi.org/10.1016/B978-0-443-15717.
• Evaluating the biological activity of rolB-transgenic Nicotiana tabacum plants using phytochemical and pharmacological approaches. Anwar, A……….Murtaza I, Mirza B*.Plant Biosystems, An International Journal Dealing with all Aspects of Plant Biology (TPLB). 2024, TPLB 2421234, 10.1080/11263504.2024.2421234.
• Cardio-protective effect of tetra (aniline) containing terpolymers through miR-15a-5p and MFN-2 regulation against hypertrophic responses.  Mushtaq I, …..,  Murtaza I* . Archives of Biochemistry and Biophysics, 2023, 747, 109763. 
• In Silico, In Vitro, and In Vivo Evaluation of Caffeine-Coated Nanoparticles as a Promising Therapeutic Avenue for AML through NF-Kappa B and TRAIL Pathways Modulation. Siddique MH, … Murtaza I , M Anees Pharmaceuticals. 2023; 16(12):1742. https://doi.org/10.3390/ph16121742
• A cohort study investigating the role of Bisphenol A in the molecular pathogenesis of breast cancer. A Ishtiaq, ….  Murtaza I*. Journal of Cancer Research and Clinical Oncology, 2023, 149 (16), 14565-14575.
• Profiling of Targeted miRNAs (8-nt) for the Genes Involved in Type 2 Diabetes Mellitus and Cardiac Hypertrophy.  Hussain, K., Ishtiaq, A., Mushtaq, I.,  Murtaza I*. Mol Biol 2023, (Springer Nature) , https://doi.org/10.1134/S0026893323020085.
• CYP2C19*17 association with higher plasma 4-hydroxy tamoxifen in Pakistani (estrogen-positive) breast cancer patients. Tareen MU, Riaz S, ……,  Murtaza I , Aneesa Sultan.  Experimental Biology and Medicine, 2023, 15353702231187640.
• Single crystal structure of nitro terminated Azo Schiff base: DNA binding, antioxidant, enzyme inhibitory and photo-isomerization investigation. Shaheen S, Liaqat F, Qamar S, Murtaza I, Rasheed A, Yousuf S, Ishtiaq A, Akhter Z. Journal of Molecular Structure. 2023,1284 (135376). https://doi.org/10.1016/j.molstruc.2023.135376.
• Epigenetic Modulation: An Unexplored Aspect of rolB Gene in Transgenic Plants. Anwar, A., Zafar, I., Muzaffar, M. B Mirza and  Murtaza I*. Russ J Plant Physiol 2023, 70, 28. https://doi.org/10.1134/S102144372260194X.
• Anti-diabetic potential, crystal structure, molecular docking, DFT, and optical-electrochemical studies of new dimethyl and diethyl carbamoyl-N, N′-disubstituted based thioureas. Khan M, …., Mirza B, Badshah A,  Murtaza I*.  Journal of Molecular Structure. 2022, Volume 1253, 132207.
•  Neuroprotective Effect of Otostegia limbata Against PTZ-Induced Mice Model of Epilepsy by Attenuated Expression of p-NFκB and TNF-α. Amin F, … Murtaza I. Front Neurosci. 2022 Mar 22;16:779681. doi: 10.3389/fnins.2022.779681. PMID: 35392411; PMCID: PMC8982360.
• Combined efficacy of Cinnamomum zeylanicum and doxorubicin against leukemia through regulation of TRAIL and NF-kappa B pathways in rat model. Bukhari, S., …  Murtaza, I.,  Vanhara,  P., Anees, M. Mol Biol Rep 2022, 49, 6495–6507 https://doi.org/10.1007/s11033-022-07478-y.
• C-Reactive Protein and High-Sensitive Cardiac Troponins Correlate with Oxidative Stress in Valvular Heart Disease Patients. Jan MI, … Murtaza I*.  , Riaz Ullah, Amal Alotaibi, H. C. Ananda Murthy, Oxidative Medicine and Cellular Longevity, vol. 2022, Article ID 5029853, 10 pages, 2022. https://doi.org/10.1155/2022/5029853.
• N-Acetyl Cysteine, Selenium, and Ascorbic Acid Rescue Diabetic Cardiac Hypertrophy via Mitochondrial-Associated Redox Regulators. Mushtaq I, …  Murtaza I*.  Molecules. 2021; 26(23):7285. https://doi.org/10.3390/molecules26237285
• Mentha longifolia Alleviates Exogenous Serotonin-Induced Diabetic Hypoglycemia and Relieves Renal Toxicity via ROS Regulation. Ali T, Ishtiaq A, …, Murtaza I*. Plant Foods Hum Nutr. 2021 Oct 30. doi: 10.1007/s11130-021-00932-5. Epub ahead of print. PMID: 34716886.
• Melatonin abated Bisphenol A–induced neurotoxicity via p53/PUMA/Drp-1 signaling.  Ishtiaq A,  Ali T,  …  Murtaza I*.   Environ Sci Pollut Res , 2021,. https://doi.org/10.1007/s11356-020-12129-5.
• MicroRNAs in molecular technology to address global diseases bench to bedside research . Akram, N. , Shahzor, Z. , Mushtaq, I. , Ishtiaq, A. , Hussain, K. & Murtaza, I*.  EJOSAT.  2021. 1492-1500 . DOI: 10.31590/ejosat.1011033
• Vitamin E boosted the protective potential of Aloe vera in CCl4-treated rats. Fatima, R., Yasin, M.S., Anwar, H., Ullah I., Shehzad W., Murtaza I., Ali T.  Biologia 2021 https://doi.org/10.1007/s11756-021-00932-5
• Pistacia integerrima alleviated Bisphenol A induced toxicity through Ubc13/p53 signalling. Ishtiaq A, Bakhtiar A, Silas E, Saeed J, Ajmal S, Mushtaq I, Ali T, Wahedi M H, Khan W, Khan U, Anees M, Sultan A &  Murtaza I*.  Mol Biol Rep , 2020, https://doi.org/10.1007/s11033-020-05706-x.
• Melatonin acts as an antidepressant via attenuation of neuroinflammation by targeting Sirt 1/ Nrf2/HO-1 signaling.   Ali T , Hao Q, Ullah N, Rahman SU, Shah FA, Li W, He K, Zheng C, Murtaza I, Li Y, Jiang Y, Li S.  Front. Mol. Neurosci., 12 June 2020 | https://doi.org/10.3389/fnmol.2020.00096.
• Melatonin prevents neuroinflammation and relieves depression by attenuating autophagy impairment through FOXO3a regulation. Ali T, Rahman SU, Hao Q, Li W F,  Liu Z, Shah FA,  Murtaza I, Zhang Z,  Yang X, Liu G,  Li S. Journal of Pineal Research.  First published: 06 May 2020. Doi: 10.1111/JPI.12667
• Engineering electroactive and biocompatible tetra(aniline)-based terpolymers with tunable intrinsic antioxidant properties in vivo. Mushtaq I, a, Mushtaq I b, Akhter Z, Murtaza I, Qamar S, Ayub S, Mirza B, Butt TM, Janjua K, Shah FU, Zaman F. https://doi.org/10.1016/j.msec.2019.110456. Mar 2020 in MATERIALS SCIENCE ANDENGINEERING: C.
• Cross talk of serum elements, cardiac and liver enzymes in patients with HCV chronic hepatitis and hepatocellular carcinoma in Pakistani population. T Naeem, T Ali, I Mushtaq, A Ishtiaq,  Murtaza I*.  . NUST Journal of Natural Sciences 2020,  5 (1), 16-24.
• Persistent Inadequacies in Infant and Young Child Feeding Practices and Their Determinants. Anees M, ……Murtaza I, Anis RA. Journal of Food and Nutrition Research 2020, 8 (7), 347-354.
•  Cardiac hypertrophic risk markers of left ventricle and left atrium in chronic heart failure due to aortic and mitral valve disease. Jan MI, …….  Murtaza I*.  Acta Radiologica. 2020, June 22, Doi.org/10.1177/0284185120933530
• Interplay of N- acetyl cysteine and melatonin in regulating oxidative stress-induced cardiac hypertrophic factors and microRNAs.  Ali T, Mushtaq I, Maryam S, Farhan A, Saba K, Jan MI, Sultan A, Anees M, Duygu B, Hamera S, Tabassum S, Javed Q, da Costa Martins PA,  Murtaza I ^*. Archives of Biochemistry and Biophysics, (Elsevier Science Inc, USA), 2019., 661., 56-65.,
• Antioxidant Activity and Hepatotoxicity of Flavonoids and Their Metal Complexes Through Co‐Administration of β‐Cyclodextrin. Jabeen E, Janjua NK, Ahmed S, Ali T, Murtaza I, Ashraf Z, Masood N, Kalsoom S. ChemistrySelect, 2019, 4 (32), 9420-9432.,
• Interleukin-6 (-572) and Tumor Necrosis Factor alpha (-308 and-238) Polymorphisms and Risk of Knee Osteoarthritis in a Pakistani Population: A Case-Control Study.  Naqvi, S.K.B., Bibi, M.,  Murtaza I ^*, Javed Q. IJST Transactions A: Science (Springer Nature), 2019, 43(4)., 1485–1490., https://doi.org/10.1007/s40995-019-00678-5. 
• Analysis of NT-proBNP and uric acid due to left ventricle hypertrophy in the patients of aortic valve disease. MI Jan, RA Khan, A Sultan, A Ullah, A Ishtiaq,  Murtaza I*.  ^#. Pakistan Journal of Medical Sciences, (PMB, Pakistan), 2019, 35(1).,183-188.
• Apoptosis of Leukemia Cells by Oscimum basilicum Fractions Following TNF alpha Induced Activation of JNK and Caspase 3. Rehan T, MacEwan D, Shah N, Rehan T, Tahira R, Murad S, Anees M, Murtaza I, Farman M, Sultan A. Current Pharmaceutical Design, 2019 . Doi: 10.2174/1381612825666191011100826.
• Role of resistin genetic variations in knee osteoarthritis pathogenesis, a cross sectional study. SKB Naqvi, Murtaza I ^*, Q Javed*.  Molecular Biology Reports, (Springer, Netherlands), 2019, 46(3)., 2657-2663.
• In vitro bioactivities and subacute toxicity study of O. basilicum, T. vulgaris and R. officinalis. Rehan T, Tahira F, Ullah H, Tareen U, Rehan T, Anees M, Murtaza I, Sultan A.  Turkish Journal of Biochemistry, 2018,  https://doi.org/10.1515/tjb-2017-0267
• Screening and characterization of selected drugs having antibacterial potential. Javed H, Tabassum S, Erum S, Murtaza I, Muhammad A, Amin F, Nisar MF. Pak J Pharm Sci. 2018 May;31(3):933-939.
• Data of expression status of mir- 29a and its putative target mitochondrial apoptosis regulatory gene DRP-1 upon mir-15a and mir-214 inhibition. Jan MI, Khan RA,  Malik A, Ali T, Bilal M, Bo L, Sajid A, Urehman N, Waseem N, Nawab J, Ali M, Majeed A, Ahmad H, Aslam S, Hamera S, Sultan A, Anees M, Javed Q,  Murtaza I *. Data in Brief 2018, 16, 1000-1004.
• Interplay of mitochondria apoptosis regulatory factors and microRNAs in valvular heart disease. Jan MI, Khan RA, Ali T, Bilal M, Bo L, Sajid A, Malik A, Urehman N, Waseem N, Nawab J, Ali M, Majeed A, Ahmad H, Aslam S, Hamera S, Sultan A, Anees M, Javed Q,  Murtaza I *. Archives of Biochemistry and Biophysics 2017, 633, 50-57.
• DFT predictions, synthesis, stoichiometric structures and anti-diabetic activity of Cu (II) and Fe (III) complexes of quercetin, morin, and primuletin.  Jabeen E, Janjua NK, Ahmed S, Murtaza I, Ali T, Masood N, Rizvi AS, Murtaza G.  Journal of Molecular Structure, 2017, 1150, 459-468.
• Radical scavenging propensity of Cu2+, Fe3+ complexes of flavonoids and in-vivo radical scavenging by Fe3+-primuletin. Jabeen E, Janjua NK, Ahmed S, Murtaza I, Ali T, Hameed S. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy  2017 Jan 15;171:432-438. Doi: 10.1016/j.saa.2016.08.035.
• Expression of Cucumber mosaic virus suppressor 2b alters FWA methylation and its siRNA accumulation in Arabidopsis thaliana. Sadia H, Youngsheng Y, Xiaoguang S, Safee Ullah C,  Murtaza I*.  , Lei S, Muhammad T, Xiaoying C,Rongxiang F. Biol Open. 2016 Nov 15;5(11):1727-1734. Doi: 10.1242/bio.017244.
• Clinical role of HER2 gene amplification and chromosome 17: a study on 154 IHC-equivocal cases of invasive breast carcinoma patients. M Afzal, M Amir, MJ Hassan, MS Hussain, MN Aziz, S Murad, I Murtaza, A Sultan...Tumor Biology, 2016, 37:8665–8672.               
• Effect of Hexane and Ethanol Extracts of Ten Basil Genotypes on the Growth of Selected Bacterial Strains. Tabassum Sobia, Amin Farhana, Erum Shazia, Javed H, Kazmi F, Nisar MF, Ullah I, Murtaza I , Ashraf M. International Journal of Agriculture and Biology.   2016 18(4)    735-740.                            
• Extracellular vesicles in ovarian cancer: applications to tumor biology, immunotherapy and biomarker discovery M Nawaz, F Fatima, I Nazarenko, K Ekström, I Murtaza, M Anees, A Sultan, Expert review of proteomics, 2016, 13 (4), 395-409 .
• Effect of maternal iodine supplementation on thyroid function and birth outcome in goiter endemic areas. M Anees, RA Anis, S Yousaf,  Murtaza I, A Sultan, M Arslan, M Shahab. Current medical research and opinion, 2015, 31 (4), 667-674.
• Insulin Over E xpression induces Heart Abnormalities via Reactive Oxygen Species Regulation, might be step towards Cardiac Hypertrophy. S Mushtaq, T Ali, M Gul, Q Javed, C Emanueli,  Murtaza I *. Cell. Mol. Biol, 2015,  61 (1), 30-35.                             
• Increased endogenous serotonin level in diabetic conditions may lead to cardiac valvulopathy via reactive oxygen species regulation. T Ali, H Waheed, F Shaheen, M Mahmud, Q Javed,  Murtaza I *. . Biologia, 2015, 70 (2), 273-278.      
• The erratic antibiotic susceptibility patterns of bacterial pathogens causing urinary tract infections. I Ahmed, M Sajed, A Sultan,  Murtaza I*.  , S Yousaf, B Maqsood, P Vanhara, Anees M. ...EXCLI journal, 2015, 14, 916-25.          
• Serotonin-promoted elevation of ROS levels may lead to cardiac pathologies in diabetic rat. T Ali, F Shaheen, M Mahmud, H Waheed, M Ishtiaq, Q Javed,  Murtaza I *. . Archives of Biological Sciences, 2015,  67 (2), 655-661.        
• N-Acetyl Cysteine inhibits Endothelin-1 induced ROS dependent Cardiac hypertrophy through superoxide dismutase regulation. Mushtaq S, Ali T, Javed Q, Tabassum S,  Murtaza I *. . Cell Journal, 2015,  17 (2).                
• Stress Responsive Factors Regulation in Patients Suffering from Type 2 Diabetes and Myocardial Infarction2. S Mushtaq, T Ali, F Altaf, M Abdullah,  Murtaza I *. . Turkish Journal of Medical Sciences, 2015, 45 (1), 148-152.     
• Imbalance of serum trace elements contributes its pro and anti-oxidative stress role via ROS and SOD regulation in acute leukemia: a population base study.. A Tahir, A M, A Aqeel, Y Nuzhat, AR Sobia,  Murtaza I *. . Trace Elements and Electrolytes, 2014, 32-1, 22-27. DOI 10.5414/TEX01358.
• Anti-Hematotoxic Role of Bunium persicum Seeds Differential Extract in Animal Model: ROS might be a Contributor. T Ali, K Saeed, M Abdullah,  Murtaza I *. Osong Public Health and Research Perspectives, 2014, 5(6): 358–363.
• Cardiac hypertrophy is negatively regulated by miR-541. F Liu, ….,  Murtaza I. ,K Wang, PF Li. Cell death & disease, 2014, 5 (4), e1171.                                                                                     
• miR-761 regulates the mitochondrial network by targeting mitochondrial fission factor. B Long, K Wang, N Li,  Murtaza I*.  , JY Xiao, YY Fan, CY Liu, WH Li, ...Li PF. Free Radical Biology and Medicine, 2013, 65, 371-379.
• Tumor necrosis factor-alpha gene promoter region polymorphism and the risk of coronary heart disease. GZ Asifa, A Liaquat,  Murtaza I*, SAR Kazmi, Q Javed. The Scientific World Journal, 2013, 203492. Doi: 10.1155/2013/203492. eCollection 2013.    
• Interplay of Phosphorylated Apoptosis Repressor with CARD, Casein Kinase-2 and Reactive Oxygen Species in Regulating Endothelin-1–Induced Cardiomyocyte Hypertrophy.  Murtaza I *, ….. LP Feng. IJBMS, 2013,  16 (8), 928-935.  
• Therapeutic potential of tumour necrosis factor-alpha antagonists in patients with chronic heart failure.   Murtaza I*, Q Javed,. Heart, Lung and Circulation, 2013,  22 (5), 323-327.                                                                                          
• Inhibition of Et-1–induced cardiomyocyte hypertrophy through pARC regulation of the ROS driven hypertrophic pathway.  Murtaza I *, J Qamar, HX Wang, PF Li. Clinical Biochemistry, 2011,  44 (13), S10-S11.
• miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy. Z Lin *, Murtaza I *, K Wang, J Jiao, J Gao, PF Li. Proceedings of the National Academy of Sciences, 2009, 106 (29), 12103-12108.      

Proceedings 

• Nexus of Apoptosis Repressor with Caspase Recruitment Domain, Potassium and Calcium in Acute Myeloid Leukemia. M Qasim, T Ali, I Murtaza*. Clinical Lymphoma Myeloma and Leukemia 2021, 21, S277                   

  Oxidative Stress Mediated Diabetes and Associated Metabolic Malfunctions Abrogation by Melatonin and Extract of Menthalongifolia (L.) in Insulin Resistant Diabetic Rats. S Khan, T Ali, W Khan, U Khan, I Murtaza*. Metabolism-Clinical and Experimental, 2021, 116.

  miRNAs and Endothelin: A potential nexus in the roadmap for diabetes linked cardiac complications therapeutic strategy. Ishtiaq A, Mushtaq I, Murtaza I*. Metabolism-Clinical and Experimental. 2022 Mar 1;128.

  Development of Cardiac specific Neurohormonal based diagnostic marker for Diabetes linked cardiac failure Mushtaq I, Ishtiaq A, Murtaza I*. Metabolism-Clinical and Experimental, 2022, 128.

  Mirnas as Potential Diagnostic Tool for Diabetes-Linked Myocardial Infarction.  Karim S,  Ishtiaq A.,  Murtaza I*. American Heart Journal, Volume 254, December 2022, Pages 239-240 https://doi.org/10.1016/j.ahj.2022.10.023.

  Investigating the Micrornas as Key Regulator in Diabetic Cardiomyopathy. I Azhar, A Ishtiaq, I Murtaza* American Heart Journal 254, 2022,  239

  Exploring the Role of Micro Rnas as Key Regulators of Diabetic Nephropathy Induced Cardiovascular Diseases. J Nawaz, I Mushtaq, I Murtaza*. American Heart Journal 2022 254, 248.                 

  Micro Rnas as Potential Biomarkers for Early-Stage Diagnosis of Hyperglycemia Induced Cardiac Autoimmunity. R Gul, I Mushtaq, I Murtaza*. American Heart Journal 2022 254, 242.                      

  In-Silico Profiling of Mirnas Against Type 2 Diabetes Mellitus and Myocardial Infarction Associated Genes. K Hussain, M Yousaf, I Murtaza*. American Heart Journal  2022, 254, 244-245.

  MiRNAs as a Therapeutic Target for Vascular Dysfunction in Diabetes. Naeem A,  Ishtiaq A, .,  Murtaza I*..  Metabolism 2023, 142 (155467)

  Identification of miRNA Targeting Genes Involved in Hyperlipidemia as a Therapeutic Strategy for Cardiovascular Diseases. Hussain K, Thahiem S, Ishtiaq A ,  Murtaza I*. American Heart Journal. Volume 267, January 2024, Page 125-PROCEEDING

  Diagnostic Potential of miRNA-15a-5p for the Early Detection of Myocardial Infarction. A Naeem, A Saeed, SL Tayyab, A Ishtiaq, I Murtaza. American Heart Journal 267, January 2024, Page 123- PROCEEDING.

  Identifying potential mirnas and hub genes for coronary artery disease prognosis using integrative approaches. Nursing and Allied Professions Investigator. Award Heart Failure 2024. I Murtaza et al. European Journal of Heart Failure 2024, 26 (S2), 3-643 ( 433)   

  Profiling of miRNAs involved in sympatho-excitation as a therapeutic strategy to combat atrial fibrillation. S Thahiem, F Iftekhar, A Ishtiaq, MI Jan, Murtaza I*. European Journal of Heart Failure 2024 , 26 (S2), 3-643 ( 622-623)                

  Profiling of Putative miRNAs (8-mer) Against the T2DM and MI Associated Genes. K Hussain, A Ishtiaq, Murtaza I*. Jun 2024. Metabolism-Clinical and Experimental. #0033. Volume 153, Supplement 155849.

UNGA Session 78- September 2023

https://sciencesummitunga78.sched.com/event/1Nrfe/global-impact-of-frugal-innovation-on-healthcare-systems

UNGA Session 79-September 2024

https://ungaguide.com/events/role-of-science-diplomacy-in-transducing-boundaries-to-respond-to-emerging-global-health-challenges/

European Society of Cardiology

https://esc365.escardio.org/person/525663

Allied Health Science Award 2024

European Society of Cardiology, Heart Failure Association 2019 

https://esc365.escardio.org/presentation/200219

International Congress of Biochemistry and Molecular Biology organized by:

International union of biochemistry and molecular biology(IUBMB)

International Federation of clinical chemistry and Laboratory medicines(IFCC)

The Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB)

EMBL Chemical Biology 2018

Royal Society of Chemistry Conference on Medicinal Chemistry and Drug Discovery 

European Society of Cardiology

Heart Failure  & World Congress in Acute Heart Failure

CAS

2010-2012

TWAS 

2011-2014

 HEC 

2012-2013

UTHSC

2015-2016

HEC

2018-2022

2019-2023