Signal Transduction and Molecular Therapeutic Interventions
Interplay of N- acetyl cysteine and melatonin in regulating oxidative stress-induced cardiac hypertrophic factors and microRNAs. Ali T, Mushtaq I, Maryam S, Farhan A, Saba K, Jan MI, Sultan A, Anees M, Duygu B, Hamera S, Tabassum S, Javed Q, da Costa Martins PA, Murtaza I *. " Arch Biochem Biophys. 2018 Nov 12;661:56-65. doi: 10.1016/j.abb.2018.11.007.
Data of expression status of mir- 29a and its putative target mitochondrial apoptosis regulatory gene DRP-1 upon mir-15a and mir-214 inhibition. Jan MI, Khan RA, Malik A, Ali T, Bilal M, Bo L, Sajid A, Urehman N, Waseem N, Nawab J, Ali M, Majeed A, Ahmad H, Aslam S, Hamera S, Sultan A, Anees M, Javed Q, Murtaza I *. Data in Brief 2018, 16, 1000-1004.
Interplay of mitochondria apoptosis regulatory factors and microRNAs in valvular heart disease. MI Jan, R A Khan, T Ali, M Bilal, L Bo, A Sajid, AMalik, N Urehman, N Waseem, JNawab, M Ali, A Majeed, H Ahmad, S Aslam, S Hamera , A Sultan, M Anees , Q Javed, I Murtaza *. Arch Biochem Biophys. 2017 Sep 6;633:50-57. doi: 10.1016/j.abb.2017.09.001. [Epub ahead of print]
DFT predictions, synthesis, stoichiometric structures and anti-diabetic activity of Cu (II) and Fe (III) complexes of quercetin, morin, and primuletin. E Jabeen, N K Janjua, S Ahmed, I Murtaza, T Ali, N Masood, A S Rizvi, G Murtaza. Journal of Molecular Structure. Volume 1150, 15 December 2017, Pages 459-468
Radical scavenging propensity of Cu2+, Fe3+ complexes of flavonoids and in-vivo radical scavenging by Fe3+-primuletin. Jabeen E, Janjua NK, Ahmed S, Murtaza I, Ali T, Hameed S.Spectrochim Acta A Mol Biomol Spectrosc. 2017 Jan 15;171:432-438. doi: 10.1016/j.saa.2016.08.035. Epub 2016 Aug 22.
Extracellular vesicles in ovarian cancer: applications to tumor biology, immunotherapy and biomarker discovery M Nawaz, F Fatima, I Nazarenko, K Ekström, I Murtaza, M Anees, A Sultan, ...Expert review of proteomics, 2016, 13 (4), 395-409
Clinical role of HER2 gene amplification and chromosome 17: a study on 154 IHC-equivocal cases of invasive breast carcinoma patients. M Afzal, M Amir, MJ Hassan, MS Hussain, MN Aziz, S Murad, I Murtaza, A Sultan...
Tumor Biology, 2016,1-8.
Effect of maternal iodine supplementation on thyroid function and birth outcome in goiter endemic areas. M Anees, RA Anis, S Yousaf, I Murtaza, A Sultan, M Arslan, M Shahab. Current medical research and opinion, 2015, 31 (4), 667-674
Insulin Over Expression induces Heart Abnormalities via Reactive Oxygen Species Regulation, might be step towards Cardiac Hypertrophy. S Mushtaq, T Ali, M Gul, Q Javed, C Emanueli, I Murtaza *. Cell. Mol. Biol, 2015, 61 (1), 30-35.
Increased endogenous serotonin level in diabetic conditions may lead to cardiac valvulopathy via reactive oxygen species regulation. T Ali, H Waheed, F Shaheen, M Mahmud, Q Javed, I Murtaza *. Biologia, 2015, 70 (2), 273-278.
The erratic antibiotic susceptibility patterns of bacterial pathogens causing urinary tract infections. I Ahmed, M Sajed, A Sultan, I Murtaza, S Yousaf, B Maqsood, P Vanhara, Anees M. ...EXCLI journal, 2015, 14, 916.
N-Acetyl Cysteine inhibits Endothelin-1 induced ROS dependent Cardiac hypertrophy through superoxide dismutase regulation. Mushtaq S, Ali T, Javed Q, Tabassum S, I Murtaza *. Cell Journal, 2015, 17 (2).
Stress Responsive Factors Regulation in Patients Suffering from Type 2 Diabetes and Myocardial Infarction2. S Mushtaq, T Ali, F Altaf, M Abdullah, I Murtaza *. TJMS, 2015, 45 (1), 148-152.
Anti-Hematotoxic Role of Bunium persicum Seeds Differential Extract in Animal Model: ROS might be a Contributor. T Ali, K Saeed, M Abdullah, I Murtaza *. Osong Public Health and Research Perspectives, 2014, 5(6): 358–363.
Cardiac hypertrophy is negatively regulated by miR-541. F Liu, N Li, B Long, YY Fan, CY Liu, QY Zhou, I Murtaza, K Wang, PF Li. Cell death & disease, 2014, 5 (4), e1171.
Imbalance of serum trace elements contributes its pro and anti-oxidative stress role via ROS and SOD regulation in acute leukemia: a population base study.. A Tahir, A M, A Aqeel, Y Nuzhat, AR Sobia, M Iram *. Trace Elements and Electrolytes, 2014, 32-1, 22-27. DOI 10.5414/TEX01358.
miR-761 regulates the mitochondrial network by targeting mitochondrial fission factor. B Long, K Wang, N Li, I Murtaza, JY Xiao, YY Fan, CY Liu, WH Li, .... Free Radical Biology and Medicine, 2013, 65, 371-379.
Tumor necrosis factor-alpha gene promoter region polymorphism and the risk of coronary heart disease. GZ Asifa, A Liaquat, I Murtaza, SAR Kazmi, Q Javed. The Scientific World Journal, 2013, 203492. doi: 10.1155/2013/203492. eCollection 2013.
Interplay of Phosphorylated Apoptosis Repressor with CARD, Casein Kinase-2 and Reactive Oxygen Species in Regulating Endothelin-1–Induced Cardiomyocyte Hypertrophy. I Murtaza*, HX Wang, S Mushtaq, Q Javed, LP Feng. IJBMS, 2013, 16 (8), 928-935.
Therapeutic potential of tumour necrosis factor-alpha antagonists in patients with chronic heart failure. Q Javed, I Murtaza. Heart, Lung and Circulation, 2013, 22 (5), 323-327.
miR-23a functions downstream of NFATc3 to regulate cardiac hypertrophy. Z Lin *, I Murtaza *, K Wang, J Jiao, J Gao, PF Li. Proceedings of the National Academy of Sciences, 2009, 106 (29), 12103-12108.
Down-regulation of catalase and oxidative modification of protein kinase CK2 lead to the failure of apoptosis repressor with caspase recruitment domain to inhibit cardiomyocyte hypertrophy. I Murtaza*, HX Wang, X Feng, N Alenina, M Bader, BS Prabhakar, PF Li. Journal of biological chemistry, 2008, 283 (10), 5996-6004.
International Congress of Biochemistry and Molecular Biology organized by:
International union of biochemistry and molecular biology(IUBMB)
International Federation of clinical chemistry and Laboratory medicines(IFCC)
The Federation of Asian and Oceanian Biochemists and Molecular Biologists (FAOBMB)
EMBL Chemical Biology
Royal Society of Chemistry Conference on Medicinal Chemistry and Drug Discovery
TWAS –COMSTECH research grant.
Therapeutic interventional study for lethal pathological disorders by employing ROS regulating endogenous factors.
HEC research grant
Novel therapeutic intervention for inhibiting cardiac hypertrophy by elucidating molecular signaling mechanism of specific transcription factors and cardiac specific ARC protein
HEC research grant
Regulation of Mitochondrial functioning to inhibit cardiomyocytes hypertrophy leading to heart failure.