The The department of Mathematics, which is under the Faculty of Natural Sciences, is one of the oldest departments that started functioning when the University was established in 1967. The brief history of the Mathematics Department at Quaid-i-Azam University is probably matched by only a few mathematics departments in the country.

The department has the honour of having some eminent scholars on its faculty. The research production of mathematics has been outstanding in the context of Pakistan. Its faculty members have been actively engaged in research and they have set some extra-ordinary trends in mathematical research in Pakistan. The department currently has 16 members on its academic staff.
Despite its limited faculty and resources, the department has established close collaboration with several national and international institutions. Most of the collaborative research work is done on the basis of individual efforts of the faculty members of the department.